MozartV1, PascalFrancis, Corpus, bibRecord, 000024

Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats

Identifieur interne : 000024 ( PascalFrancis/Corpus ); précédent : 000023; suivant : 000025

Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats

Auteurs : Lung-Chang Lin ; Chun-Ting Juan ; Hsueh-Wen Chang ; Ching-Tai Chiang ; Ruey-Chang Wei ; Mei-Wen Lee ; Hin-Kiu Mok ; Rei-Cheng Yang

Source :

Epilepsy research [ 0920-1211 ] ; 2013.

RBID : Pascal:13-0202475

Descripteurs français

Pascal (Inist)
- Epilepsie, Convulsion, Tension électrique, Décharge rythmique, Pointe positive, Rat, Animal.

English descriptors

KwdEn :
- Animal, Convulsion, Epilepsy, Rat, Rhythmic discharge, Spike, Voltage.

Abstract

Purpose: Recent research has revealed more evidence supporting the positive effects of music on humans and animals. However, evidence of music's effects on improving epilepsy in animals is sparse. This study aimed to clarify the influence of Mozart's music in Long Evans rats, which are characterized by spontaneous absence epilepsy (SAE) and high-voltage rhythmic spike (HVRS) discharges. Methods: Continuous electroencephalograms comprised of HVRS discharges, and behavioral performance were recorded in Long Evans rats (n = 5) before, during, and after exposure to the Mozart's Sonata for Two Pianos in D Major, K.448 (Mozart K.448). The same evaluation was repeated after they had been subjected to daily exposure of the music for 20 days. Results: Seizure frequencies and spontaneous HVRS discharges were reduced in all of the SAE rats during and after music exposure compared with the pre-music stage. The average seizure frequencies were 79.8±24.6, 48±15.2, and 33±2.1/h before, during, and after music exposure, respectively. The average run of spike episodes were 84.6±18.4, 52±17.8, and 36.8±16.9/h before, during, and after music exposure, respectively. The seizure frequencies and related run of spike episodes decreased by 39.8% and 38.5% during, and 58.6% and 56.6% post music exposure, respectively. The average run of spike durations and spike numbers also showed significant decreases (reduction by 47.1%, 47.8% during music and 60.8%, 61.3% post music). After daily music exposure for 20 days, the number of HVRS discharges and seizure frequencies during and after music exposure, however, showed no further accumulative reduction or adaptation effect. These results suggest that Mozart K.448 had a positive short-term effect in attenuating the spontaneous HVRS discharges in Long Evans rats. However, the mechanism needs further investigation.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 EPIRE8`
A03		`1`		`@0 Epilepsy res.`
A05				`@2 104`
A06				`@2 3`
A08	`01`	`1`	`ENG`	`@1 Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats`
A11	`01`	`1`		`@1 LIN (Lung-Chang)`
A11	`02`	`1`		`@1 JUAN (Chun-Ting)`
A11	`03`	`1`		`@1 CHANG (Hsueh-Wen)`
A11	`04`	`1`		`@1 CHIANG (Ching-Tai)`
A11	`05`	`1`		`@1 WEI (Ruey-Chang)`
A11	`06`	`1`		`@1 LEE (Mei-Wen)`
A11	`07`	`1`		`@1 MOK (Hin-Kiu)`
A11	`08`	`1`		`@1 YANG (Rei-Cheng)`
A14	`01`			`@1 Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University @2 Kaohsiung City 80708 @3 TWN @Z 1 aut.`
A14	`02`			`@1 Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University @2 Kaohsiung City 80708 @3 TWN @Z 1 aut. @Z 8 aut.`
A14	`03`			`@1 Institute of Marine Biology, National Sun Yat-Sen University @2 Kaohsiung City 80424 @3 TWN @Z 2 aut. @Z 7 aut.`
A14	`04`			`@1 Department of Biological Science, National Sun Yat-Sen University @2 Kaohsiung City 80424 @3 TWN @Z 3 aut.`
A14	`05`			`@1 Department of Computer and Communication, National Pingtung Institute of Commerce @2 Pingtung @3 TWN @Z 4 aut.`
A14	`06`			`@1 Institute of Undersea Technology and Applied Marine Physics, National Sun Yat-Sen University @2 Kaohsiung City 80424 @3 TWN @Z 5 aut.`
A14	`07`			`@1 Department of Music, National Sun Yat-Sen University @2 Kaohsiung City 80424 @3 TWN @Z 6 aut.`
A14	`08`			`@1 Department of Pediatrics, Changhua Christian Hospital @2 Changhua @3 TWN @Z 8 aut.`
A20				`@1 234-240`
A21				`@1 2013`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 21149 @5 354000503795290060`
A44				`@0 0000 @1 © 2013 INIST-CNRS. All rights reserved.`
A45				`@0 3/4 p.`
A47	`01`	`1`		`@0 13-0202475`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Epilepsy research`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Purpose: Recent research has revealed more evidence supporting the positive effects of music on humans and animals. However, evidence of music's effects on improving epilepsy in animals is sparse. This study aimed to clarify the influence of Mozart's music in Long Evans rats, which are characterized by spontaneous absence epilepsy (SAE) and high-voltage rhythmic spike (HVRS) discharges. Methods: Continuous electroencephalograms comprised of HVRS discharges, and behavioral performance were recorded in Long Evans rats (n = 5) before, during, and after exposure to the Mozart's Sonata for Two Pianos in D Major, K.448 (Mozart K.448). The same evaluation was repeated after they had been subjected to daily exposure of the music for 20 days. Results: Seizure frequencies and spontaneous HVRS discharges were reduced in all of the SAE rats during and after music exposure compared with the pre-music stage. The average seizure frequencies were 79.8±24.6, 48±15.2, and 33±2.1/h before, during, and after music exposure, respectively. The average run of spike episodes were 84.6±18.4, 52±17.8, and 36.8±16.9/h before, during, and after music exposure, respectively. The seizure frequencies and related run of spike episodes decreased by 39.8% and 38.5% during, and 58.6% and 56.6% post music exposure, respectively. The average run of spike durations and spike numbers also showed significant decreases (reduction by 47.1%, 47.8% during music and 60.8%, 61.3% post music). After daily music exposure for 20 days, the number of HVRS discharges and seizure frequencies during and after music exposure, however, showed no further accumulative reduction or adaptation effect. These results suggest that Mozart K.448 had a positive short-term effect in attenuating the spontaneous HVRS discharges in Long Evans rats. However, the mechanism needs further investigation.
C02	`01`	`X`		`@0 002B17A03`
C03	`01`	`X`	`FRE`	`@0 Epilepsie @5 01`
C03	`01`	`X`	`ENG`	`@0 Epilepsy @5 01`
C03	`01`	`X`	`SPA`	`@0 Epilepsia @5 01`
C03	`02`	`X`	`FRE`	`@0 Convulsion @5 02`
C03	`02`	`X`	`ENG`	`@0 Convulsion @5 02`
C03	`02`	`X`	`SPA`	`@0 Convulsión @5 02`
C03	`03`	`X`	`FRE`	`@0 Tension électrique @5 03`
C03	`03`	`X`	`ENG`	`@0 Voltage @5 03`
C03	`03`	`X`	`SPA`	`@0 Voltaje @5 03`
C03	`04`	`X`	`FRE`	`@0 Décharge rythmique @5 04`
C03	`04`	`X`	`ENG`	`@0 Rhythmic discharge @5 04`
C03	`04`	`X`	`SPA`	`@0 Descarga rítmica @5 04`
C03	`05`	`X`	`FRE`	`@0 Pointe positive @5 05`
C03	`05`	`X`	`ENG`	`@0 Spike @5 05`
C03	`05`	`X`	`SPA`	`@0 Espiga positiva @5 05`
C03	`06`	`X`	`FRE`	`@0 Rat @5 06`
C03	`06`	`X`	`ENG`	`@0 Rat @5 06`
C03	`06`	`X`	`SPA`	`@0 Rata @5 06`
C03	`07`	`X`	`FRE`	`@0 Animal @5 07`
C03	`07`	`X`	`ENG`	`@0 Animal @5 07`
C03	`07`	`X`	`SPA`	`@0 Animal @5 07`
C07	`01`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`02`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`04`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`04`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 38`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
C07	`06`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 39`
C07	`06`	`X`	`ENG`	`@0 Nervous system diseases @5 39`
C07	`06`	`X`	`SPA`	`@0 Sistema nervioso patología @5 39`
C07	`07`	`X`	`FRE`	`@0 Trouble neurologique @5 40`
C07	`07`	`X`	`ENG`	`@0 Neurological disorder @5 40`
C07	`07`	`X`	`SPA`	`@0 Trastorno neurológico @5 40`
N21				`@1 189`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 13-0202475 INIST
ET :	Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats
AU :	LIN (Lung-Chang); JUAN (Chun-Ting); CHANG (Hsueh-Wen); CHIANG (Ching-Tai); WEI (Ruey-Chang); LEE (Mei-Wen); MOK (Hin-Kiu); YANG (Rei-Cheng)
AF :	Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University/Kaohsiung City 80708/Taïwan (1 aut.); Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University/Kaohsiung City 80708/Taïwan (1 aut., 8 aut.); Institute of Marine Biology, National Sun Yat-Sen University/Kaohsiung City 80424/Taïwan (2 aut., 7 aut.); Department of Biological Science, National Sun Yat-Sen University/Kaohsiung City 80424/Taïwan (3 aut.); Department of Computer and Communication, National Pingtung Institute of Commerce/Pingtung/Taïwan (4 aut.); Institute of Undersea Technology and Applied Marine Physics, National Sun Yat-Sen University/Kaohsiung City 80424/Taïwan (5 aut.); Department of Music, National Sun Yat-Sen University/Kaohsiung City 80424/Taïwan (6 aut.); Department of Pediatrics, Changhua Christian Hospital/Changhua/Taïwan (8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Epilepsy research; ISSN 0920-1211; Coden EPIRE8; Royaume-Uni; Da. 2013; Vol. 104; No. 3; Pp. 234-240; Bibl. 3/4 p.
LA :	Anglais
EA :	Purpose: Recent research has revealed more evidence supporting the positive effects of music on humans and animals. However, evidence of music's effects on improving epilepsy in animals is sparse. This study aimed to clarify the influence of Mozart's music in Long Evans rats, which are characterized by spontaneous absence epilepsy (SAE) and high-voltage rhythmic spike (HVRS) discharges. Methods: Continuous electroencephalograms comprised of HVRS discharges, and behavioral performance were recorded in Long Evans rats (n = 5) before, during, and after exposure to the Mozart's Sonata for Two Pianos in D Major, K.448 (Mozart K.448). The same evaluation was repeated after they had been subjected to daily exposure of the music for 20 days. Results: Seizure frequencies and spontaneous HVRS discharges were reduced in all of the SAE rats during and after music exposure compared with the pre-music stage. The average seizure frequencies were 79.8±24.6, 48±15.2, and 33±2.1/h before, during, and after music exposure, respectively. The average run of spike episodes were 84.6±18.4, 52±17.8, and 36.8±16.9/h before, during, and after music exposure, respectively. The seizure frequencies and related run of spike episodes decreased by 39.8% and 38.5% during, and 58.6% and 56.6% post music exposure, respectively. The average run of spike durations and spike numbers also showed significant decreases (reduction by 47.1%, 47.8% during music and 60.8%, 61.3% post music). After daily music exposure for 20 days, the number of HVRS discharges and seizure frequencies during and after music exposure, however, showed no further accumulative reduction or adaptation effect. These results suggest that Mozart K.448 had a positive short-term effect in attenuating the spontaneous HVRS discharges in Long Evans rats. However, the mechanism needs further investigation.
CC :	002B17A03
FD :	Epilepsie; Convulsion; Tension électrique; Décharge rythmique; Pointe positive; Rat; Animal
FG :	Rodentia; Mammalia; Vertebrata; Pathologie de l'encéphale; Pathologie du système nerveux central; Pathologie du système nerveux; Trouble neurologique
ED :	Epilepsy; Convulsion; Voltage; Rhythmic discharge; Spike; Rat; Animal
EG :	Rodentia; Mammalia; Vertebrata; Cerebral disorder; Central nervous system disease; Nervous system diseases; Neurological disorder
SD :	Epilepsia; Convulsión; Voltaje; Descarga rítmica; Espiga positiva; Rata; Animal
LO :	INIST-21149.354000503795290060
ID :	13-0202475

Links to Exploration step

Pascal:13-0202475

Le document en format XML

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<author><name sortKey="Mok, Hin Kiu" sort="Mok, Hin Kiu" uniqKey="Mok H" first="Hin-Kiu" last="Mok">Hin-Kiu Mok</name>
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<author><name sortKey="Yang, Rei Cheng" sort="Yang, Rei Cheng" uniqKey="Yang R" first="Rei-Cheng" last="Yang">Rei-Cheng Yang</name>
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<front><div type="abstract" xml:lang="en">Purpose: Recent research has revealed more evidence supporting the positive effects of music on humans and animals. However, evidence of music's effects on improving epilepsy in animals is sparse. This study aimed to clarify the influence of Mozart's music in Long Evans rats, which are characterized by spontaneous absence epilepsy (SAE) and high-voltage rhythmic spike (HVRS) discharges. Methods: Continuous electroencephalograms comprised of HVRS discharges, and behavioral performance were recorded in Long Evans rats (n = 5) before, during, and after exposure to the Mozart's Sonata for Two Pianos in D Major, K.448 (Mozart K.448). The same evaluation was repeated after they had been subjected to daily exposure of the music for 20 days. Results: Seizure frequencies and spontaneous HVRS discharges were reduced in all of the SAE rats during and after music exposure compared with the pre-music stage. The average seizure frequencies were 79.8±24.6, 48±15.2, and 33±2.1/h before, during, and after music exposure, respectively. The average run of spike episodes were 84.6±18.4, 52±17.8, and 36.8±16.9/h before, during, and after music exposure, respectively. The seizure frequencies and related run of spike episodes decreased by 39.8% and 38.5% during, and 58.6% and 56.6% post music exposure, respectively. The average run of spike durations and spike numbers also showed significant decreases (reduction by 47.1%, 47.8% during music and 60.8%, 61.3% post music). After daily music exposure for 20 days, the number of HVRS discharges and seizure frequencies during and after music exposure, however, showed no further accumulative reduction or adaptation effect. These results suggest that Mozart K.448 had a positive short-term effect in attenuating the spontaneous HVRS discharges in Long Evans rats. However, the mechanism needs further investigation.</div>
</front>
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<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0920-1211</s0>
</fA01>
<fA02 i1="01"><s0>EPIRE8</s0>
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<fA03 i2="1"><s0>Epilepsy res.</s0>
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<fA05><s2>104</s2>
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<fA06><s2>3</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>LIN (Lung-Chang)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>JUAN (Chun-Ting)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>CHANG (Hsueh-Wen)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>CHIANG (Ching-Tai)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>WEI (Ruey-Chang)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>LEE (Mei-Wen)</s1>
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<fA11 i1="07" i2="1"><s1>MOK (Hin-Kiu)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>YANG (Rei-Cheng)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University</s1>
<s2>Kaohsiung City 80708</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University</s1>
<s2>Kaohsiung City 80708</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
<sZ>8 aut.</sZ>
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<fA14 i1="03"><s1>Institute of Marine Biology, National Sun Yat-Sen University</s1>
<s2>Kaohsiung City 80424</s2>
<s3>TWN</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Biological Science, National Sun Yat-Sen University</s1>
<s2>Kaohsiung City 80424</s2>
<s3>TWN</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Computer and Communication, National Pingtung Institute of Commerce</s1>
<s2>Pingtung</s2>
<s3>TWN</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Institute of Undersea Technology and Applied Marine Physics, National Sun Yat-Sen University</s1>
<s2>Kaohsiung City 80424</s2>
<s3>TWN</s3>
<sZ>5 aut.</sZ>
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<fA14 i1="07"><s1>Department of Music, National Sun Yat-Sen University</s1>
<s2>Kaohsiung City 80424</s2>
<s3>TWN</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Department of Pediatrics, Changhua Christian Hospital</s1>
<s2>Changhua</s2>
<s3>TWN</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>234-240</s1>
</fA20>
<fA21><s1>2013</s1>
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<fA43 i1="01"><s1>INIST</s1>
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<s1>© 2013 INIST-CNRS. All rights reserved.</s1>
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<fA45><s0>3/4 p.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>13-0202475</s0>
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<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
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<fA64 i1="01" i2="1"><s0>Epilepsy research</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Purpose: Recent research has revealed more evidence supporting the positive effects of music on humans and animals. However, evidence of music's effects on improving epilepsy in animals is sparse. This study aimed to clarify the influence of Mozart's music in Long Evans rats, which are characterized by spontaneous absence epilepsy (SAE) and high-voltage rhythmic spike (HVRS) discharges. Methods: Continuous electroencephalograms comprised of HVRS discharges, and behavioral performance were recorded in Long Evans rats (n = 5) before, during, and after exposure to the Mozart's Sonata for Two Pianos in D Major, K.448 (Mozart K.448). The same evaluation was repeated after they had been subjected to daily exposure of the music for 20 days. Results: Seizure frequencies and spontaneous HVRS discharges were reduced in all of the SAE rats during and after music exposure compared with the pre-music stage. The average seizure frequencies were 79.8±24.6, 48±15.2, and 33±2.1/h before, during, and after music exposure, respectively. The average run of spike episodes were 84.6±18.4, 52±17.8, and 36.8±16.9/h before, during, and after music exposure, respectively. The seizure frequencies and related run of spike episodes decreased by 39.8% and 38.5% during, and 58.6% and 56.6% post music exposure, respectively. The average run of spike durations and spike numbers also showed significant decreases (reduction by 47.1%, 47.8% during music and 60.8%, 61.3% post music). After daily music exposure for 20 days, the number of HVRS discharges and seizure frequencies during and after music exposure, however, showed no further accumulative reduction or adaptation effect. These results suggest that Mozart K.448 had a positive short-term effect in attenuating the spontaneous HVRS discharges in Long Evans rats. However, the mechanism needs further investigation.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17A03</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Epilepsie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Epilepsy</s0>
<s5>01</s5>
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<s5>01</s5>
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<s5>02</s5>
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<s5>02</s5>
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<fC03 i1="02" i2="X" l="SPA"><s0>Convulsión</s0>
<s5>02</s5>
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<fC03 i1="03" i2="X" l="FRE"><s0>Tension électrique</s0>
<s5>03</s5>
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<s5>03</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Voltaje</s0>
<s5>03</s5>
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<s5>04</s5>
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<s5>04</s5>
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<s5>05</s5>
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<s5>05</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>Rat</s0>
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</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Rat</s0>
<s5>06</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Rata</s0>
<s5>06</s5>
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<s5>07</s5>
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<s5>07</s5>
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<s5>07</s5>
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<s2>NS</s2>
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<s2>NS</s2>
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<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>38</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
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<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
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<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
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<s5>40</s5>
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<s5>40</s5>
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</fN21>
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<server><NO>PASCAL 13-0202475 INIST</NO>
<ET>Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats</ET>
<AU>LIN (Lung-Chang); JUAN (Chun-Ting); CHANG (Hsueh-Wen); CHIANG (Ching-Tai); WEI (Ruey-Chang); LEE (Mei-Wen); MOK (Hin-Kiu); YANG (Rei-Cheng)</AU>
<AF>Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University/Kaohsiung City 80708/Taïwan (1 aut.); Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University/Kaohsiung City 80708/Taïwan (1 aut., 8 aut.); Institute of Marine Biology, National Sun Yat-Sen University/Kaohsiung City 80424/Taïwan (2 aut., 7 aut.); Department of Biological Science, National Sun Yat-Sen University/Kaohsiung City 80424/Taïwan (3 aut.); Department of Computer and Communication, National Pingtung Institute of Commerce/Pingtung/Taïwan (4 aut.); Institute of Undersea Technology and Applied Marine Physics, National Sun Yat-Sen University/Kaohsiung City 80424/Taïwan (5 aut.); Department of Music, National Sun Yat-Sen University/Kaohsiung City 80424/Taïwan (6 aut.); Department of Pediatrics, Changhua Christian Hospital/Changhua/Taïwan (8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Epilepsy research; ISSN 0920-1211; Coden EPIRE8; Royaume-Uni; Da. 2013; Vol. 104; No. 3; Pp. 234-240; Bibl. 3/4 p.</SO>
<LA>Anglais</LA>
<EA>Purpose: Recent research has revealed more evidence supporting the positive effects of music on humans and animals. However, evidence of music's effects on improving epilepsy in animals is sparse. This study aimed to clarify the influence of Mozart's music in Long Evans rats, which are characterized by spontaneous absence epilepsy (SAE) and high-voltage rhythmic spike (HVRS) discharges. Methods: Continuous electroencephalograms comprised of HVRS discharges, and behavioral performance were recorded in Long Evans rats (n = 5) before, during, and after exposure to the Mozart's Sonata for Two Pianos in D Major, K.448 (Mozart K.448). The same evaluation was repeated after they had been subjected to daily exposure of the music for 20 days. Results: Seizure frequencies and spontaneous HVRS discharges were reduced in all of the SAE rats during and after music exposure compared with the pre-music stage. The average seizure frequencies were 79.8±24.6, 48±15.2, and 33±2.1/h before, during, and after music exposure, respectively. The average run of spike episodes were 84.6±18.4, 52±17.8, and 36.8±16.9/h before, during, and after music exposure, respectively. The seizure frequencies and related run of spike episodes decreased by 39.8% and 38.5% during, and 58.6% and 56.6% post music exposure, respectively. The average run of spike durations and spike numbers also showed significant decreases (reduction by 47.1%, 47.8% during music and 60.8%, 61.3% post music). After daily music exposure for 20 days, the number of HVRS discharges and seizure frequencies during and after music exposure, however, showed no further accumulative reduction or adaptation effect. These results suggest that Mozart K.448 had a positive short-term effect in attenuating the spontaneous HVRS discharges in Long Evans rats. However, the mechanism needs further investigation.</EA>
<CC>002B17A03</CC>
<FD>Epilepsie; Convulsion; Tension électrique; Décharge rythmique; Pointe positive; Rat; Animal</FD>
<FG>Rodentia; Mammalia; Vertebrata; Pathologie de l'encéphale; Pathologie du   système nerveux central; Pathologie du système nerveux; Trouble neurologique</FG>
<ED>Epilepsy; Convulsion; Voltage; Rhythmic discharge; Spike; Rat; Animal</ED>
<EG>Rodentia; Mammalia; Vertebrata; Cerebral disorder; Central nervous system disease; Nervous system diseases; Neurological disorder</EG>
<SD>Epilepsia; Convulsión; Voltaje; Descarga rítmica; Espiga positiva; Rata; Animal</SD>
<LO>INIST-21149.354000503795290060</LO>
<ID>13-0202475</ID>
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Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats

Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats

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